CEO , Stem cell lab 360, MEXICO
Title: Deep wounds regeneration in diabetic foot patients, through the use of a biological scaffold (BIOANDAMIOÂ®) constructed with extracellular matrix molecules, aliginate and microvesicles derived from endometrial mesenchymal stem cells.
Biologist Ricardo Rangel has 20 years of experience in the development of biotechnological platforms for the isolation of adult stem cells, as well as in the development of preclinical and clinical protocols for private industry. He is CEO of the company Stemcylab and CryoVida Mexico.
The biotechnological advance around the knowledge of the mesenchymal stem cells has led us to explore the bio-activity of diverse molecules and subcellular derivatives thereof. Currently, more than 800 clinical trials are being carried out according to the clinicaltrials.gov database, which demonstrates the enormous interest that exists in regenerative medicine. In the last ten years a large amount of evidence has accumulated of the therapeutic effect that can be attributed to mesenchymal stem cells. These cells can be isolated from various tissue sources, the most common being those obtained from the bone marrow, adipose tissue, dental pulp and embryonic attachments such as placenta and Wharton's gelatin.In the endometrial tissue, it has been proven since 2008, that it is a source of mesenchymal stem cells with a high therapeutic value since it possesses properties superior to those of other sources of these cells. One of them is the large number of molecules related to angiogenic processes, which are altered in conditions such as ulcers secondary to type II diabetes mellitus. In addition to producing anti-inflammatory and immunomodulation molecules, important in the regenerative process. Regenerative cell-free medicine in an emerging discipline that raises the use of stem cell derivatives as therapeutic agents. Microvesicles are subcellular components that have a great importance in inter-cellular communication at the local and systemic level. These microvesicles are loaded with bioactive molecules and microRNAs, which have been shown to be sufficient to allow the processes of immunomodulation and cell regeneration. For the first time, here we demonstrate the important regenerative potenical of microvesicles isolated from the mesenchymal stem cells of endometrial tissue in the resolution of deep wounds in diabetic patients. (Case reports).